Bacterial Toxins Fuel Disease Progression in Cutaneous T-Cell Lymphoma
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چکیده
منابع مشابه
Bacterial Toxins Fuel Disease Progression in Cutaneous T-Cell Lymphoma
In patients with cutaneous T-cell lymphoma (CTCL) bacterial infections constitute a major clinical problem caused by compromised skin barrier and a progressive immunodeficiency. Indeed, the majority of patients with advanced disease die from infections with bacteria, e.g., Staphylococcus aureus. Bacterial toxins such as staphylococcal enterotoxins (SE) have long been suspected to be involved in...
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Bacterial toxins including staphylococcal enterotoxins (SEs) have been implicated in the pathogenesis of cutaneous T-cell lymphomas (CTCLs). Here, we investigate SE-mediated interactions between nonmalignant T cells and malignant T-cell lines established from skin and blood of CTCL patients. The malignant CTCL cells express MHC class II molecules that are high-affinity receptors for SE. Althoug...
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ژورنال
عنوان ژورنال: Toxins
سال: 2013
ISSN: 2072-6651
DOI: 10.3390/toxins5081402